By William Kemp
Get the large photograph of Pathology - and concentrate on what you really want to grasp to attain excessive at the path and board examination if you would like a streamlined and definitive examine Pathology - one with simply the appropriate stability of data to provide you the sting at examination time - flip to Pathology: the large photograph. you will find a succinct, hassle-free presentation specifically designed to make even the main complicated idea comprehensible within the shortest volume of research time attainable. This excellent pictorial and textual assessment of Pathology can provide: A “Big photo” emphasis on what you want to comprehend verses “what's great to grasp” specialist authorship via award-winning, lively teachers assurance of the whole diversity of pathology subject matters - every thing from mobile variations and harm to genetic problems to irritation to illnesses of immunity really good 4-color illustrations quite a few precis tables and figures for speedy reference and speedy retention of even the main tough subject Highlighted key ideas that underscore quintessential elements of histology (key recommendations also are indexed in a desk on the finish of every bankruptcy) USMLE-type questions, solutions, and factors that can assist you count on what you will come upon at the checks and lots more and plenty extra!
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Extra info for Pathology: The Big Picture
1. , angiogenesis). 2. Migration and proliferation of ﬁbroblasts. 3. Deposition of extracellular matrix. 4. Maturation and reorganization of fibrous tissue. Tissue remodeling is a balance between extracellular matrix synthesis and degradation. , collagenases, gelatinases). Time frame of scarring ■ Within 24 hours of onset of acute inﬂammation, the process of scarring begins. ■ At 3–5 days, granulation tissue is formed. The term granulation tissue indicates a proliferation of ﬁbroblasts, new thinwalled vessels, and loose extracellular matrix.
ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) Cause: Infection with human immunodeﬁciency virus (HIV), an RNA retrovirus. Mechanism of transmission ■ Sexual: Virus is in semen (extracellular and in monocytes) and enters the patient through tears in the mucosa. , IV drug abuse). ■ Mother-to-infant: Transmission can occur in utero, transplacental, or intrapartum (during delivery). Types ■ HIV-1: Found in individuals in the United States, Europe, and Central Africa. ■ HIV-2: Found in individuals in West Africa.
2. Synthesize growth factor receptors. For example, • RET receptor for glial cell line-derived neurotrophic factor—in medullary and papillary thyroid carcinoma (MEN syndrome). • ERB B1, an epidermal growth factor (EGF) receptor, is overexpressed in squamous cell carcinoma of the lung. • ERB B2, an EGF receptor, is overexpressed in 25% of breast carcinomas. 3. Synthesize signal-transducing proteins: An example of a speciﬁc gene is the RAS gene. • Incidence of mutations in RAS gene: Mutations of the RAS gene are in 30% of all malignant neoplasms and in 90% of pancreatic adenocarcinomas.