By Adam Greenspan M.D. FACR, Gernot Jundt MD, Wolfgang Remagen MD
This quantity offers either the radiologist's and the pathologist's method of differential analysis of musculoskeletal tumors and tumor-like lesions and info the radiologic and histopathologic good points valuable in confirming a prognosis. The ebook is illustrated with over 1,200 radiographs, CT and MR photos, full-color photomicrographs, and schematic drawings. Tables record vital diagnostic positive factors, and schematic drawings summarize either radiologic and pathologic differential diagnoses.
This variation contains cutting-edge info on puppy, thin-section CT, 3-D CT, MRI, enzyme histochemistry, immunohistochemistry, circulate cytometry, cytogenetics, and molecular cytogenetics. the recent co-author, Gernot Jundt, used to be instrumental in revising the WHO class of musculoskeletal lesions. Illustrations were up-to-date, and superior captions commence with the diagnosis.
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Additional resources for Differential diagnosis in orthopaedic oncology
Assessment of malignancy of cartilage tumors using flow cytometry. J Bone Joint Surg Am 1983;65A:779–785. 4. Alho A, Skjeldal S, Pettersen EO, et al. Aneuploidy in benign tumors and nonneoplastic lesions of musculoskeletal tissues. Cancer 1994;73:1200–1205. 5. Amann G, Zoubek A, Salzer-Kuntschik M, et al. Relation of neurological marker expression and EWS gene fusion types in MIC2/CD99-positive tumors of the Ewing family. Hum Pathol 1999;30:1058–1064. 6. An Y, Martin K, eds. Handbook of histological methods for bone and cartilage.
In several respects, however, CT unquestionably rivals MRI. MR images do not clearly depict calcifications in the tumor matrix or allow it to be characterized as readily as CT. In fact, large amounts of calcification and ossification have occasionally gone almost undetected by MRI (195). In addition, MRI demonstration of cortical destruction and periosteal reaction is less satisfactory than that of CT or even of radiography (67,191). Although neither technique is usually suitable for establishing the precise nature of a bone tumor (except perhaps the characteristic MRI features of intraosseous lipoma and hemangioma), much faith has been placed in MRI in particular as a method capable of distinguishing benign from malignant lesions (16,47,76,93,109).
They can be detected in small amounts in tumors of the Ewing family, such as PNETs or classical Ewing sarcomas, and especially in neuroblastomas (149,201). GFAP is present in glial cells and is almost never used in studies of bone tumor pathology (162). Antibodies Against Hematopoietic and Lymphoid Cells Antibodies against hematopoietic and lymphoid cells are widely used in the diagnosis of lymphomas and B A Figure 1-37 Enzyme histochemistry. A: Alkaline phosphatase. A small round bone trabecula (center) is surrounded by stroma typical for fibrous dysplasia.